In the wake of the unsuccessful 2023 referendum on constitutional recognition of First Nations Australians, governments and public agencies need to provide more effective policy support for Indigenous-led initiatives to meet Closing the Gap targets across sectors. The Indigenous-led primary health care sector can serve as a model, Dr Matt Fisher, Associate Professor Emma George and Professor Fran Baum from the University of Adelaide, Associate Professor Tamara McKean from Flinders University, and Professor Sharon Friel from the Australian National University write.